ALGEBRAIC MODELS OF BIOCHEMICAL NETWORKS

作者:Laubenbacher Reinhard*; Jarrah Abdul Salam
来源:METHODS IN ENZYMOLOGY: COMPUTER METHODS, PART B , ELSEVIER ACADEMIC PRESS INC, 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA, 163-+, 2009.
DOI:10.1016/S0076-6879(09)67007-5

摘要

With the rise of systems biology as an important paradigm in the life sciences and the availability and increasingly good quality of high-throughput molecular data, the role of mathematical models has become central in the understanding of the relationship between structure and function of organisms. This chapter focuses on a particular type of models, so-called algebraic models, which are generalizations of Boolean networks. It provides examples of such models and discusses several available methods to construct such models from high-throughput time course data. One specific such method, Polynome, is discussed in detail.

  • 出版日期2009
  • 单位美国弗吉尼亚理工大学(Virginia Tech)

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