Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice

作者：Li, Xi-jing; Liu, Da-peng; Chen, Hua-lin; Pan, Xiu-hua; Kong, Qing-yan; Pang, Qing-feng^*

来源：International Immunopharmacology, 2012, 12(2): 460-464.

DOI：10.1016/j.intimp.2012.01.001

• Lactoferrin
• Lipopolysaccharide
• Acute lung injury

Lactoferrin (LF) plays various anti-inflammatory roles in inflammation experimentally induced by lipopolysaccharides (U'S). But the protective effects of LF on LPS-induced acute lung injury (ALI) have not been elucidated. In this study, we aimed to study the effects of LF on ALI caused by LPS in mice. At 1 h before or after U'S injection, an intraperitoneal injection of LF (5 mg/body) was administered. Lung specimens and the bronchoalveolar lavage fluid (BALF) were isolated for histopathological examinations and biochemical analyses 12 h after U'S exposure. We found that both prophylactic and therapeutic administration of IF significantly decreased the W/D ratio of the lung and protein concentration in the BALF. LF significantly reduced the pulmonary myeloperoxidase activity and the number of total cells in the BALF 12 h after LPS challenge. LF treatment markedly attenuated lung edema, alveolar hemorrhage and inflammatory cells infiltration. Moreover, LF also decreased the production of TNF-alpha and increased interleukin-10 in the BALF. These results firstly indicate that LF may protect against LPS-induced ALI in mice.

• 出版日期2012-2
• 单位徐州医科大学