A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population

作者：Lim Seung Taek; Yu Jong Han; Park Heung Kyu; Moon Byung In; Ko Byung Kyun; Suh Young Jin^*

来源：World Journal of Surgical Oncology, 2014, 12(1): 56.

DOI：10.1186/1477-7819-12-56

• Invasive lobular carcinoma
• Invasive ductal carcinoma
• Molecular subtype
• Breast cancer-specific survival
• Overall survival

Background: To investigate the clinicopathological characteristics and the survival outcomes of invasive lobular carcinoma (ILC) patients compared to invasive ductal carcinoma (IDC) patients according to their molecular subtype. %26lt;br%26gt;Methods: We compared the clinicopathological characteristics, breast cancer-specific survival (BCSS) and overall survival (OS) between patients with IDC (n = 14,547) and ILC (n = 528). %26lt;br%26gt;Results: The ILC presented with a larger tumor size, more advanced cancer stage, increased rate of hormonal receptor positivity, human epidermal growth factor 2 (HER2) negativity and mastectomy than the IDC. The ILC patients more frequently presented with the luminal A subtype, whereas the IDC patients more frequently presented with the luminal B, HER2-overexpression, or triple negative subtype. The BCSS and OS were not significantly different between the IDC and ILC for each molecular subtype. %26lt;br%26gt;Conclusions: Similar to IDC patients, molecular subtype should be considered when determining the prognosis and treatment regimen for ILC patients.

• 出版日期2014-3-13