Asymmetric hydrogenation of 1-silyl-1-substituted alkenes for preparation of optically active silanes

作者：Ma, Dan-Dan; Gu, Peiming; Li, Rui^*

来源：Tetrahedron Letters, 2016, 57(50): 5666-5668.

DOI：10.1016/j.tetlet.2016.11.017

• Asymmetric hydrogenation
• Silyl alkenes
• Ir catalyst

Asymmetric hydrogenation of 1-silyl-1-substituted alkenes has been explored, producing eight optically active silanes with good to excellent enantioselectivity (66-99% ee) and yield (74-99%). The reaction was efficiently catalyzed by the cationic N,P-Ir complexes, and the polar solvents were found to be essential for the stereocontrol of the conversion.

• 出版日期2016-12-14
• 单位宁夏大学