New 2-Benzoxazolinone Derivatives with Cytotoxic Activities from the Roots of Acanthus ilicifolius

作者：Zhao, Dan; Xie, Lijun; Yu, Lei; An, Ni; Na, Wei; Chen, Feng; Li, Youbin; Tan, Yinfeng^*; Zhang, Xiaopo

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2015, 63(12): 1087-1090.

DOI：10.1248/cpb.c15-00597

• Acanthus ilicifolius
• 2-benzoxazolinone
• cytotoxic activity

Four new 2-benzoxazolinone-type alkaloids (acanthosides A-D) along with three known ones were isolated from the roots of Acanthus ilicifolius. Their structures were established by detailed interpretation of one dimensional (1D)- and two dimensional (2D)-NMR as well as high-resolution electrospray ionization (ESI)-MS data. The antiproliferative activities of these compounds were evaluated in vitro against three cultured cancer cell lines. The new compounds exhibited different levels of cytotoxicity against the HepG2, HeLa, and A-549 cancer cell lines with IC50 range 7.8-26.6 mu m. In comparison with known compounds, the new isolates displayed better cytotoxic activities, which was attributable to the presence of substituted benzoyl moiety in their structures.

• 出版日期2015-12
• 单位哈尔滨商业大学; 福建省微生物研究所; 海南医学院