The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment

作者：Chang Nakho; Ahn Sun Hee; Kong Doo Sik; Lee Hye Won^*; Nam Do Hyun^*

来源：Molecular and Cellular Endocrinology, 2017, 451(C): 53-65.

DOI：10.1016/j.mce.2017.01.004

• Signal transducer and activator of transcription 3
• Glioblastoma multiforme
• Tumor progression
• Tumor microenvironment
• Prognosis
• Therapeutic target

Glioblastoma multiforme (GBM) is the most aggressive form of cancer that begins within the brain; generally, the patient has a dismal prognosis and limited therapeutic options. Signal transducer and activator of transcription 3 (STAT3) is a critical mediator of tumorigenesis, tumor progression, and suppression of anti-tumor immunity in GBM. In a high percentage of GBM cells and tumor microenvironments, persistent activation of STAT3 induces cell proliferation, anti-apoptosis, glioma stem cell maintenance, tumor invasion, angiogenesis, and immune evasion. This makes STAT3 an attractive therapeutic target and a prognostic indicator in GBM. Targeting STAT3 affords an opportunity to disrupt multiple pro-oncogenic pathways at a single molecular hub. Unfortunately, there are no successful STAT3 inhibitors currently in clinical trials. However, strong clinical evidence implicating STAT3 as a major factor in GBM justifies the identification of safe and effective strategies for inhibiting STAT3.

• 出版日期2017-8-15