Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

作者:Kavruk M; Celikbicak O; Ozalp V C*; Borsa B A; Hernandez F J; Bayramoglu G; Salih B; Arica M Y
来源:Chemical communications, 2015, 51(40): 8492-8495.
DOI:10.1039/c5cc01869b

摘要

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

  • 出版日期2015
  • 单位test