科研之友
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摘要
A palladium-catalyzed intermolecular gamma-arylation of gamma-branched alpha,beta-unsaturated aldehydes has been developed. The reaction allows congested quaternary centers to be forged on a remote position from the carbonyl group, affording a variety of products in high yield and with consistently high stereoselectivity using very low catalyst loadings. The synthetic utility of the products has been highlighted by a series of derivatizations and the potential of the method to be extended to remote epsilon-functionalization has been demonstrated.
- 出版日期2013
