MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells

作者：Yasui Kiyoshi; Izumida Mai; Nakagawa Takeya; Kubo Yoshinao; Hayashi Hideki; Ito Takashi; Ikeda Hiroaki; Matsuyama Toshifumi^*

来源：Biochemical and Biophysical Research Communications, 2018, 501(4): 833-837.

DOI：10.1016/j.bbrc.2018.04.159

• ATLL
• Drug resistance
• miR-3662
• IRF-4
• c-Rel

Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2 kb of binding sites, including MIR3662. Expression of miR-3662 was regulated by IRF4, and to a lesser extent by c-Rel. Cell proliferation was inhibited by knockdown of miR-3662 and expression of miR-3662 was correlated with antiviral drug resistance in ATLL cell lines. Thus, miR-3662 represents a target for therapies against ATLL.

• 出版日期2018-7-2