Assessment of antinociceptive and anti-inflammatory activities of Porophyllum ruderale aqueous extract

作者：Lima Gabrielle M; Bonfim Rangel R; Silva Monica R; Thomazzi Sara M; Santos Marcio R V; Quintans Junior Lucindo J; Bonjardim Leonardo R; Araujo Adriano A S^*

来源：Brazilian Journal of Pharmacognosy, 2011, 21(3): 486-490.

DOI：10.1590/S0102-695X2011005000051

• Porophyllum ruderale
• medicinal plant
• antinociceptive activity
• anti-inflammatory activity

The present work investigated the antinociceptive and anti-inflammatory activities of the Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract (PRAE). For this purpose, acetic acid writhing, paw licking induced by formalin, hot-plate and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg (p. o.) significantly inhibited the writhing 63.4, 89.6 and 94.8%, respectively, in comparison with control group. The lick of the paw 1(st) phase was reduced at the dose of 400 mg/kg (24.9%), while the 2(nd) phase had reduction at doses 200 and 400 mg/kg (23.1 and 34.4%), respectively. The PRAE inhibited the carrageenan-induced neutrophil migration to the peritoneal cavity in a higher dose (p<0.05). Taken together, our results suggest that the PRAE can constitute target potential for use in therapies of the pain and inflammation.

• 出版日期2011-6