An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst

作者：Li Ji Tai^*; Zhai Xin Li; Lin Zhi Ping; Zhang Xiao Hui

来源：Letters in Organic Chemistry, 2008, 5(7): 579-582.

DOI：10.2174/157017808785982103

• 7,11-Diarylspiro[5.5]undecane-1,9-dione
• synthesis
• ultrasound irradiation
• Michael condensation
• phase-transfer catalysis

Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5-bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.

• 出版日期2008-10
• 单位河北大学