Drug-Eluting Stents Ameliorate Pulmonary Vein Stenotic Changes in Pigs In Vivo

作者：Furukawa Takeshi^*; Kishiro Masahiko; Fukunaga Hideo; Ohtsuki Masahiro; Takahashi Ken; Akimoto Katsumi; Shimizu Toshiaki; Kawasaki Shiori; Kumasaka Toshio

来源：Pediatric Cardiology, 2010, 31(6): 773-779.

DOI：10.1007/s00246-010-9695-8

• Drug-eluting stents
• In-stent stenosis
• Porcine
• Pulmonary vein
• Sirolimus

The outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness remains unknown. In this study, three bare-metal stents (BMSs) and three sirolimus-eluting stents (SESs) were implanted in 1-month-old pigs. The pigs were killed 8 weeks later to compare in-stent stenosis rates. The extent of neointimal thickness, as measured by injury score, was significantly less in the SES group than in the BMS group (injury score 1: BMS 0.351 +/- A 0.033 vs SES 0.226 +/- A 0.031 mm; P < 0.01; injury score 2: BMS 1.232 +/- A 0.244 vs SES 0.609 +/- A 0.208 mm; P < 0.01). The pathologic findings showed confluence of inflammatory cells around the stent wires in BMS-treated areas and granuloma formation. Granuloma formation was not seen with SES. The degree of in-stent stenosis was significantly reduced in the SES group, suggesting that the use of drug-eluting stents is an effective treatment for PVS. Because of the small sample size and the considerable variation in injury scores and balloon-to-vein ratios, future studies with larger samples are necessary.

• 出版日期2010-8