General and Mild Ni-0-Catalyzed alpha-Arylation of Ketones Using Aryl Chlorides

作者：Fernandez Salas Jose A; Marelli Enrico; Cordes David B; Slawin Alexandra M Z; Nolan Steven P^*

来源：Chemistry - A European Journal, 2015, 21(10): 3906-3909.

DOI：10.1002/chem.201406457

• aryl chlorides
• cross-coupling reactions
• ketone arylation
• N-heterocyclic carbenes
• nickel
• synthetic methods

A general methodology for the alpha-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin) Cl] (1c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni-N-heterocyclic carbene (NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni-0/Ni-II catalytic cycle to be at play.

• 出版日期2015-3-2