Anti-cancer characteristics of mevinolin against three different solid tumor cell lines was not solely p53-dependent

作者：Mahmoud Ali Mokhtar; Al Abd Ahmed M; Lightfoot David A; El Shemy Hany A^*

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, 27(5): 673-679.

DOI：10.3109/14756366.2011.607446

• Mevinolin
• Doxorubicin
• Solid tumors
• natural products
• p53

Mevinolin (MVN) has been used clinically for the treatment of hypercholesterolemia with very good tolerance by patients. Based on epidemiological evidences, MVN was suggested strongly for the treatment of neoplasia. Early experimental trials suggested the mixed apoptotic/necrotic cell death pathway was activated in response to MVN exposure. Herein, the cytotoxic profile of MVN was evaluated, compared to the robust and frequently used anticancer drug doxorubicin (DOX), against breast (MCF-7), cervical (HeLa) and liver (HepG(2)) transformed cell lines. MVN was showed comparable results in cytotoxic profile with DOX in all tested solid tumor cell lines. In addition, the MVN-induced cytotoxicity was inferred to be multi-factorial and not solely dependent on p53 expression. It was concluded that molecular and genetic assessment of MVN-induced cell death would be useful for developing cancer therapeutic treatments.

• 出版日期2012-10