Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B)

作者：Gevorkian Goar^*; Gonzalez Noriega Alfonso; Acero Gonzalo; Ordonez Jorge; Michalak Colette; Munguia Maria Elena; Govezensky Tzipe; Cribbs David H; Manoutcharian Karen

来源：Neurochemistry International, 2008, 52(6): 1030-1036.

DOI：10.1016/j.neuint.2007.10.020

• amyloid-beta peptide
• phage displayed cDNA library
• microtubule-associated protein 1B (MAP1B)

Extracellular and intraneuronal formation of amyloid-beta aggregates have been demonstrated to be involved in the pathogenesis of Alzheimer's disease. However, the precise mechanism of amyloid-beta neurotoxicity is not completely understood. Previous studies suggest that binding of amyloid-beta to a number of targets have deleterious effects on cellular functions. In the present study we have shown for the first time that amyloid-beta 1-42 bound to a peptide comprising The microtubule binding domain of the heavy chain of microtubule-associated protein 1B by the screening of a human brain cDNA library expressed on M13 phage. This interaction may explain, in part, the loss of neuronal cytoskeletal integrity, impairment of microtubule-dependent transport and synaptic dysfunction observed previously in Alzheimer's disease.

• 出版日期2008-5