An Expedient Synthesis of Bis-Fused Benzofuran and a Two-Directional Ring-Closing Metathesis for the Synthesis of Bisbenzoxepines and Bisbenzoxocines

作者：Majumdar Krishna C^*; Chattopadhyay Buddhadeb; Chakravorty Santanu

来源：Synthesis, 2009, 2009(4): 674-680.

DOI：10.1055/s-0028-1083339

• palladium catalyst
• Grubbs catalyst
• intramolecular cyclization
• two-directional ring-closing metathesis
• 5-exo-trig
• benzofuran
• oxepine
• oxocine

Synthesis of bis-fused benzofuran derivatives by the implementation of palladium-mediated intramolecular cyclization is described. To our knowledge, this is the first report of the synthesis of bis-fused benzofuran by this protocol. Bisbenzoxepine and bisbenzoxocine derivatives were also synthesized by the application of two-directional ring-closing metathesis.

• 出版日期2009-2-16