Blood-brain barrier disruption is associated with increased mortality after endovascular therapy

作者：Desilles Jean Philippe; Rouchaud Aymeric; Labreuche Julien; Meseguer Elena; Laissy Jean Pierre; Serfaty Jean Michel; Lapergue Bertrand; Klein Isabelle F; Guidoux Celine; Cabrejo Lucie; Sirimarco Gaia; Lavallee Philippa C; Schouman Claeys Elisabeth; Amarenco Pierre; Mazighi Mikael^*

来源：Neurology, 2013, 80(9): 844-851.

DOI：10.1212/WNL.0b013e31828406de

Objective: To evaluate the incidence, baseline characteristics, and clinical prognosis of blood-brain barrier (BBB) disruption after endovascular therapy in acute ischemic stroke patients. %26lt;br%26gt;Methods: A total of 220 patients treated with endovascular therapy between April 2007 and October 2011 were identified from a prospective, clinical, thrombolysis registry. All patients underwent a nonenhanced CT scan immediately after treatment. CT scan or MRI was systematically realized at 24 hours to assess intracranial hemorrhage complications. BBB disruption was defined as a hyperdense lesion on the posttreatment CT scan. %26lt;br%26gt;Results: BBB disruption was found in 128 patients (58.2%; 95% confidence interval [CI], 51.4%-64.9%). Cardioembolic etiology, high admission NIH Stroke Scale score, high blood glucose level, internal carotid artery occlusion, and use of combined endovascular therapy (chemical and mechanical revascularization) were independently associated with BBB disruption. Patients with BBB disruption had lower rates of early major neurologic improvement (8.6% vs 31.5%, p %26lt; 0.001), favorable outcome (39.8% vs 61.8%, p = 0.002), and higher rates of 90-day mortality (34.4% vs 14.6%, p = 0.001) and hemorrhagic complications (42.2% vs 8.7%, p %26lt; 0.001) than those without BBB disruption. By multivariable analysis, patients with BBB disruption remained with a lower rate of early neurologic improvement (adjusted odds ratio [OR], 0.28; 95% CI, 0.11-0.70) and with a higher rate of mortality (adjusted OR, 2.37; 95% CI, 1.06-5.32) and hemorrhagic complications (adjusted OR, 6.38; 95% CI, 2.66-15.28). %26lt;br%26gt;Conclusion: BBB disruption has a detrimental effect on outcome and is independently associated with mortality after endovascular therapy. BBB disruption assessment may have a role in prognosis staging in these patients. Neurology (R) 2013; 80:844-851

• 出版日期2013-2