Natural history of spheno-orbital meningiomas

作者：Saeed Peerooz^*; van Furth Wouter R; Tanck Michael; Kooremans Fabio; Freling Nicole; Streekstra Geert I; Regen**urg Noortje I; van der Sprenkel Jan Willem Berkelbach; Peerdeman Saskia M; van Overbeeke Jakobus J; Mourits Maarten P

来源：Acta Neurochirurgica, 2011, 153(2): 395-402.

DOI：10.1007/s00701-010-0878-0

• Spheno-orbital meningiomas
• Orbital meningiomas
• Natural history
• Volumetry
• Imaging
• Orbitaltumors

To investigate the natural history and the growth rate of spheno-orbital meningiomas (SOMs).
Ninety patients with a diagnosis of SOM were included, and patient charts and imaging were evaluated. In a subset of 32 patients, volumetric studies were performed.
The median follow-up for the entire group was 4 years (range, 1-15); the mean age was 47.8 (range, 26-93) years; 94% of the patients were female. The most common clinical signs and symptoms were proptosis (93%), visual deterioration (65%), retro-bulbar pain (23%) and diplopia (6%). In 35% of patients in this series, no visual deterioration occurred, and in 30% only mild proptosis was present. The median annual growth rate of the SOMs in the subset of 32 patients was 0.3 cm(3)/year (range, 0.03-1.8 cm(3)/year). We assessed a trend for more rapid tumour growth in younger patients and found the initial volume of the tumour (rho = 0.63) and of the soft tissue component (rho = 074) to be significantly related to the growth rate.
SOMs are slow-growing tumours that cause primarily proptosis and visual deterioration. In a significant number of patients, these tumours cause minimal discomfort and symptomatology. Therefore, in the absence of risk factors, we advocate a "wait and see" policy. For patients with large SOMs or with a large soft tissue component at first visit or with fast growing SOMs (> 1cm(3)/year), a follow-up examination every 6 months is indicated.

• 出版日期2011-2