Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

作者：da Cruz Rodrigo B; Galdino Pablinny M; Penna Karlla G B D; Hoffmann Karen; Costa Elson A^*; Bataus Luiz A M

来源：Anais da Academia Brasileira de Ciencias, 2013, 85(2): 595-603.

• Streptoverticillium
• anti-inflammatory effect
• nociceptive and inflammatory models
• phospholipase A(2) activity

The Streptoverticillium sp. Z1 is an actinomycete isolated from the soil under Cerrado vegetation, the extract of this strain was investigated in nociceptive and inflammatory models. The Streptoverticillium extract (ExS) 50 and 100 mg/kg (s.c.) produced a significant inhibition of acetic acid-induced abdominal writhings thereby demonstrating an anti-nociceptive effect. In the tail flick test the ExS (s.c.) was inactive. This result implited that ExS does not contain opioid-like compounds with central analgesic properties. In the inflammatory models, ExS 100 and 200 mg/kg (s.c.) were able to inhibit the croton oil-induced ear edema and, ExS 200 and 500 mg/kg (s.c.) inhibited the leukocyte migration on the carrageenan-induced peritonitis. The phospholipase A(2) enzymatic assay showed that the anti-inflammatory activity of ExS was not due to direct effect on phospholipase A(2) activity. These data suggest that Streptoverticillium sp. produces metabolites with anti-inflammatory effect and that these metabolites are unable to directly inhibit phospholipase A(2) enzyme.

• 出版日期2013-6