A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors

作者：Davydow Dimitry S^*; Kohen Ruth; Hough Catherine L; Tracy Julia Helen; Zatzick Douglas; Katon Wayne J

来源：Journal of Critical Care, 2014, 29(1): 101-106.

DOI：10.1016/j.jcrc.2013.08.016

• Critical care
• Posttraumatic stress disorder
• Depression
• Corticotrophin-releasing hormone binding protein
• Corticotrophin-releasing hormone receptor-type 1

Purpose: To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization.
Materials and Methods: We extracted DNA for genotyping from saliva samples of 93 ICU patients enrolled in a prospective cohort investigation. Follow-up interviews conducted 3 and 12-months post-ICU included assessment of PTSD symptoms with the PTSD Checklist-Civilian Version and depressive symptoms with the Patient Health Questionnaire-9.
Results: Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (beta = -10.8, 95% confidence interval [95% CI],-17.7 to-3.9; P = .002) and depressive symptoms (beta = -3.7, 95% CI, -6.7 to -0.7; P = .02). Carrying a CRHR1 rs1876831 C allele was associated with significantly more post-ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: beta = 6.9, 95% CI, 1.2-12.6; P = .02; C/C homozygotes: beta = 5.8; 95% CI: 0.2-11.3; P = .04). These associations remained significant after adjustment for age, race, illness severity, and in-ICU steroid exposure.
Conclusions: Despite a small sample size, our findings suggest a potential role for genetic variants of CRHBP and CRHR1 in the development of post-ICU psychiatric morbidity.

• 出版日期2014-2