Dupuytren's disease therapy: targeting the vicious cycle of myofibroblasts?

作者：Musumeci Maria^*; Vadala Gianluca; Russo Fabrizio; Pelacchi Federica; Lanotte Angela; Denaro Vincenzo

来源：Expert Opinion on Therapeutic Targets, 2015, 19(12): 1677-1687.

DOI：10.1517/14728222.2015.1068758

• Dupuytren's disease
• molecular mechanisms
• myofibroblasts
• therapeutic strategies

Introduction: Dupuytren's disease (DD) is a proliferative fibromatosis of the hand, which causes permanent flexion contracture of the digits and, ultimately, loss of function. The treatment of DD is complex and involves surgical and nonsurgical approaches, with the goal of removing the affected tissue. New biological targets are under investigation in order to develop innovative therapies.Areas covered: The etiology of DD is still unknown. Several authors who focused their studies on the genetics of DD recognized an inherited autosomal dominant pattern. Actually, DD is a multifactorial and complex disease. Myofibroblasts are thought to play a crucial role in its pathogenesis, although their origin is not clear.Expert opinion: There is a general consensus that a better understanding of cellular and molecular mechanisms of DD will lead to the design of more specific and effective treatment alternatives. In this review, the authors hypothesize a new biological model for DD pathology, where myofibroblasts enhance the reservoir of the disease acting as if in a vicious cycle. This could help, ultimately, in identifying new therapeutic strategies to treat this common and disabling fibroproliferative disorder.

• 出版日期2015-12-2