Antiphage activity of sera during phage therapy in relation to its outcome

作者：Lusiak Szelachowska Marzanna^*; Zaczek Maciej; Weber Dabrowska Beata; Miedzybrodzki Ryszard; Letkiewicz Slawomir; Fortuna Wojciech; Rogoz Pawel; Szufnarowski Krzysztof; Jonczyk Matysiak Ewa; Olchawa Ewa; Walaszek Kinga M; Gorski Andrzej

来源：Future Microbiology, 2017, 12(2): 109-117.

DOI：10.2217/fmb-2016-0156

• antibiotic resistance
• bacterial infections
• bacteriophages
• clinical results
• human sera
• phage neutralization
• phage therapy

Aim: The aim was to study the association between the phage neutralization of patients' sera and the clinical outcome of phage therapy (PT). Patients: About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied.Materials & methods: Antiphage activity of sera (AAS) was examined using the phage neutralization test of different types of phages before and during PT in relation to the route of phage administration and correlated with the results of PT. Results & conclusion: The analysis of the association between AAS level and clinical results indicated that the level of AAS is not correlated with the outcome of PT.

• 出版日期2017-2
• 单位河北医科大学