Anterior Intratumoural Chemotherapy: A Newer Modality of Treatment in Advanced Solid Tumours in Children

作者：Gangopadhyay A N^*; Rajeev Rahi; Sharma S P; Upadhyaya Vijai D; Arya N C; Kumar Vijayendra; Gopal S C

来源：Asian Journal of Surgery, 2008, 31(4): 225-229.

DOI：10.1016/S1015-9584(08)60092-5

• advanced solid tumours
• intratumoural chemotherapy
• intravenous chemotherapy
• paediatric tumours

OBJECTIVE: Advanced and inoperable solid tumours in children have high mortality despite aggressive multimodal treatment. Intravenous chemotherapy is abandoned at times because of systemic toxicity. This Study investigated intratumoural chemotherapy and compared it with intravenous chemotherapy.
METHODS: Forty children with advanced inoperable solid tumours (Wilms' tumour and neuroblastoma) were randomly allocated into two groups of 20. Group A was given intratumoural chemotherapy and group B was given intravenous chemotherapy. Both groups were compared for reduction in tumour Size and Volume, tumour resectability, histopathological changes and drug side effects.
RESULTS: Intratumoural chemotherapy was Superior to intravenous chemotherapy in terms reducing turnout size and volume (63% in group A vs. 22% in group B). The resectability was 70% in the intratumoural group compared with 40% in the intravenous group. The overall good histopathological response was 71% in group A as opposed to 0% in group B. Moreover, the incidence and severity of drug side effects and morbidity were less with intratumoural chemotherapy. Mortality was also low Ill group A (5%) compared to group B (20%).
CONCLUSION: Intratumoural chemotherapy can be offered as an effective and safe alternative treatment modality For advanced and inoperable Wilms' turnout and neuroblastoma. [Asian J Surg 2008; 31(4):225-9]

• 出版日期2008-10
• 单位河北医科大学