Effects of Carnoy's solution on blood vessels of the axillary fossa of rats

作者：Saulacic N^*; Stajcic Z; Stajcic L J Stojcev; Piattelli A; Lizuka T; Lombardi T

来源：International Journal of Oral and Maxillofacial Surgery, 2009, 38(8): 876-879.

DOI：10.1016/j.ijom.2009.04.001

• Carnoy's solution
• blood vessel
• peripheral nerve
• rat

Carnoy's Solution is applied to reduce the recurrence of odontogenic keratocysts and unicystic ameloblastomas. The deleterious action of this fixative oil nerves has been studied but no attention has been paid to its effects oil nearby vessels. The aim of this study was to investigate the effects of Carnoy's Solution Oil blood vessels. The rat axillary artery and vein were Surgically exposed, soaked with Carnoy's Solution and kept in place for 2, 5 or 10 min, depending oil the treatment group. The 5-mm group was followed for 1, 2 and 3 weeks postoperatively. The vessels in the 2-min and 5-min exposure groups showed histological changes to the vessels, represented by focal loss of the endothelium and hyalinization of the wall. These alterations increased in the 10-min group. The vessels in the 3-week observation period revealed signs of recovery. It is Concluded that Carnoy's Solution can damage blood vessels but the process is reversible for exposure times less than 5 min.

• 出版日期2009-8