Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis

作者：Shen, Liang; Zhuang, Qi-Shuai; Ji, Hong-Fang^*

来源：Molecular Nutrition & Food Research, 2016, 60(5): 1059-1067.

DOI：10.1002/mnfr.201500937

• Metaanalysis
• Type 1 diabetes
• Type 2 diabetes
• Vitamin D

Scope: Accumulating evidence indicates that vitamin D deficiency is prevalent in patients with type 1 (T1D) and type 2 diabetes (T2D). The present study aims to assess 25-hydroxyvitamin D [25(OH) D] levels in T1D and T2D patients compared with controls through a metaanalysis.
Methods and results: We searched databases for articles published until January 2015. A total of 12 studies covering 2003 patients and 1882 controls and 11 studies covering 2236 patients and 2438 controls were included to metaanalyze 25(OH) D levels in patients with T1D and T2D, respectively. Pooled data showed that T1D patients had lower levels of 25(OH) D than controls (summary standardized mean difference (SMD) -0.70, 95% confidence interval (CI) -1.02 to -0.37). Further age-subgroup analysis found that 25(OH) D levels in T1D patients was also significantly lower than controls in subgroup aged <= 14 years (summary SMD -1.04, 95% CI -1.55 to -0.53), while the association is not statistically significant in the subgroup aged > 14 years. Similarly, T2Dpatients had lower 25(OH) D levels compared with controls (summary SMD -0.58, 95% CI -1.16 to -0.00).
Conclusion: Available data indicated that both T1D and T2D patients had lower levels of 25(OH) D than controls overall. The mechanistic underpinnings of this association warrant further elucidation.

• 出版日期2016-5
• 单位山东理工大学; 上海生物信息技术研究中心