A Mild and Regioselective Ring-Opening of Aziridines with Acid Anhydride Using TBD or PS-TBD as a Catalyst

作者：Matsukawa Satoru^*; Mouri Yasutaka

来源：Molecules, 2015, 20(10): 18482-18495.

DOI：10.3390/molecules201018482

• organocatalyst
• basecatalyst
• polymercatalyst
• guanidine
• aziridine
• amino alcohols

The ring-opening of N-tosylaziridines with various acid anhydrides catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding -amino esters in excellent yields under mild reaction conditions. Polymer-supported catalyst, PS-TBD also acts as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal loss of activity.

• 出版日期2015-10