Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia

作者：Djuric Tamara^*; Zivkovic Maja; Stankovic Aleksandra; Dincic Evica; Raievic Rarlko; Alavantic Dragan

来源：Journal of the Neurological Sciences, 2008, 267(1-2): 62-65.

DOI：10.1016/j.jns.2007.09.037

• MMP-3
• gene polymorphism
• multiple sclerosis
• MSSS

Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from Serbia. A total of 184 MS patients (150 RR, 34 SP) and 236 controls have been studied. Results show that the distribution of MMP-3 5A/6A genotype frequencies between NIS patients and controls were not significantly different. In bout onset patients, carriers of MMP-3 6A/6A genotype had significantly higher mean MSSS values compared to the carriers of 5A allele (6.29 +/- 1.89 vs. 5.29 +/- 2.62, respectively, ANCOVA, p=0.01 Scheffe post-hoc test). In conclusion, our results indicate association of MMP-3 6A/6A genotype with significantly higher mean MSSS values. Thus, the obtained results suggest that it should be carefully considered during follow up of patients with MS. Further genetic and functional studies are needed to resolve the complex role of MMPs and their tissue inhibitors in NIS pathology and/or regeneration.

• 出版日期2008-4-15
• 单位中国人民解放军军事医学科学院