Macrocyclic bis-urea receptor: Synthesis, crystal structure and phosphate binding properties

作者：Shu, Xi; Wang, Ruyu; Fan, Yu; Li, Shoujian; Huang, Chao^*

来源：Tetrahedron Letters, 2019, 60(10): 729-733.

DOI：10.1016/j.tetlet.2019.02.004

• Macrocyclic bis-urea
• Anion-binding
• Crystal structure
• NMR titration

A macrocyclic bis-urea receptor (L1) and two acyclic bis-urea analogues (L2 and L3) have been synthesized. The crystal structure of L1 was obtained. The experimental results show that the receptor L1 has high selectivity to H2PO4-. Meanwhile, compared with the acyclic receptors L2 and L3, L1 has higher binding ability to H2PO4-. The results of density functional theory (DFT) calculations deepened our understanding on L1 conformations stability and its anion-binding property.

• 出版日期2019-3-7
• 单位四川大学