摘要
Acyclic amines 1 were obtained by a nucleophilic aromatic substitution (SNAr) reaction and N-methylation followed by silane reduction. The optical resolution of C(aryl)-N(amine) bond atropisomers of amines 1 is described. We found that chiral acyclic amine la can be resolved by crystallization without any outside chiral source. Finally, we demonstrate the ability of chiral amines 1 as a ligand in a palladium-catalyzed asymmetric allylic alkylation (up to 93 % ee).
- 出版日期2011-8