A Selective and Convenient Method for the Synthesis of 2-Phenylaminothiazolines

作者:Bernacki April L*; Zhu Lingyang; Hennings D David
来源:Organic Letters, 2010, 12(23): 5526-5529.
DOI:10.1021/ol102428m

摘要

A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described.

  • 出版日期2010-12-3