Negative regulation of TGF-β by AMPK and implications in the treatment of associated disorders

作者：Gao, Jiayu; Ye, Jinhui; Ying, Ying; Lin, Hui; Luo, Zhijun^*

来源：Acta Biochimica et Biophysica Sinica, 2018, 50(6): 523-531.

DOI：10.1093/abbs/gmy028

• TGF-beta
• AMPK
• fibrosis
• epithelial-mesenchymal transition
• angiogenesis
• heterotopic ossification

Transforming growth factor beta (TGF-beta) regulates a large number of biological processes, including proliferation, differentiation, immune response, and development. In addition, TGF-beta plays important roles in some pathological processes, for instance, it is upregulated and activated in fibrosis and advanced cancer. Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that is activated when cells sense shortage of ATP and increase in AMP or AMP: ATP ratio. Activation of AMPK slows down anabolic processes and stimulates catabolic processes, leading to increased production of ATP. Furthermore, the functions of AMPK have been extended beyond energy homeostasis. In fact, AMPK has been shown to exert a tumor suppressive effect. Recent studies have demonstrated negative impacts of AMPK on TGF-beta function. Therefore, in this review, we will discuss the differences in the biological functions of TGF-beta and AMPK, and some pathological processes such as fibrosis, epithelial-mesenchymal transition (EMT) and cancer metastasis, as well as angiogenesis and heterotopic ossifications where TGF-beta and AMPK exert opposite effects.

• 出版日期2018-6
• 单位南昌大学