High prevalence of human herpesvirus type 8 infection in patients with pulmonary tuberculosis in Taiwan

作者：Su C C^*; Lai C L; Tsao S M; Lin M N; Hsieh T C; Lu J J; Chu T Y

来源：Clinical Microbiology and Infection, 2015, 21(3): 266.e5-266.e7.

DOI：10.1016/j.cmi.2014.10.015

• HHV-8
• HIV
• immunofluorescence assay
• Kaposi sarcoma
• tuberculosis

Blood samples were collected from 101 untreated pulmonary tuberculosis (TB) patients and 101 age- and sex-matched healthy control subjects. TB patients had lower lymphocyte and a higher monocyte counts than control subjects (p < 0.0001 for both). The seropositive rate of human herpesvirus (HHV) type 8 antibody was higher in patients (30/101) than in control subjects (15/101) (p = 0.01). Antibody titres in patients also exceeded those in control subjects (p 0.006). Lymphocyte and monocyte counts between seronegative and seropositive subjects were not different. Four patients were positive for HHV-8 DNA. The study revealed a significantly higher HHV-8 seroprevalence in untreated pulmonary TB patients than in general population.

• 出版日期2015-3
• 单位河北医科大学