A Perhaps Unexpected Role of Norepinephrine in Actions of MDMA

作者:Newton T F*
来源:Clinical Pharmacology & Therapeutics, 2011, 90(2): 215-216.
DOI:10.1038/clpt.2011.125

摘要

In this issue, Hysek and colleagues present new data describing the impact of treatment with reboxetine on the effects produced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in human volunteers. They demonstrate that several effects of MDMA are mediated by reboxetine's actions on norepinephrine (NE) transporters, an unexpected finding. Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents.

  • 出版日期2011-8