Fowl typhoid in laying hens cause hepatic oxidative stress

作者：Biazus Angelisa H; Da Silva Aleksandro S; Bottari Nathieli B; Baldissera Matheus D; do Carmo Guilherme M; Morsch Vera M; Schetinger Maria Rosa C; Casagrande Renata; Guarda Naiara S; Moresco Rafael N; Stefani Lenita M; Campigotto Gabriela; Boiago Marcel M

来源：Microbial Pathogenesis, 2017, 103: 162-166.

DOI：10.1016/j.micpath.2016.12.009

• Fowl typhoid
• Nitric oxide
• Oxidative stress
• Poultry

The aim of this study was to analyses nitric oxide, antioxidant status, and oxidative profile in the liver of laying hens naturally infected by Salmonella enterica subsp enterica serovar Gallinarum (S. Gallinarum). The nitrite/nitrate (NOx), reactive oxygen species (ROS), thiobarbituric acid-reactive substances (TBARS), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities were measured in liver samples, as well the biomarkers of hepatic alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), total protein and albumin levels measured in serum. NOx levels and CAT activity were reduced in hepatic tissue of infected hens. On the other hand, TBARS and ROS levels, GR, GPx and GST activities were higher in infected animals. On biomarkers of tissue damage, ALT, AST, GGT and total protein levels were higher in serum of infected hens, and showed decreased albumin levels. In summary, ROS and TBARS production lead to damage on the membrane lipids that alter activities of antioxidant enzymes CAT, GR, GPx and GSH, an adaptive response against S. Gallinarum infection, contributing to the pathophysiology and clinical signs of the disease.

• 出版日期2017-2