Acceptance, yield and feasibility of attaching HCV birth cohort screening to colorectal cancer screening in Spain

作者：Javier Garcia Alonso Francisco; Bonillo Cambrodon Daniel; Bermejo Andrea; Garcia Martinez Jesus; Hernandez Tejero Maria; Lopez Fando Paz Valer; Piqueras Belen; Bermejo Fernando

来源：Digestive and Liver Disease, 2016, 48(10): 1237-1242.

DOI：10.1016/j.dld.2016.06.034

• Colonoscopy
• Hepatitis C
• Prevalence
• Screening

Introduction: The US Centers for Disease Control recommends hepatitis C virus (HCV) screening for baby boomers. Spain presents a similar distribution of infected patients. We performed a cross sectional prospective study to evaluate the prevalence of undiagnosed HCV infection in subjects born between 1949 and 1974.
Methods: All out-patients within the age range, both symptomatic and screening procedures, undergoing colonoscopy between December 2014 and June 2015 were offered a HCV antibody blood test and a survey including risk factors for HCV infection and attitude toward HCV screening. Patients with chronic HCV or with a previous negative HCV antibody test were excluded.
Results: A total of 570 subjects, 50% screening procedures, were analyzed. The median age was 55.7, 94.6% were born in Spain and 54.6% were women. Antibodies against HCV were found in 1.6% (95% CI: 0.8-3%) and HCV-RNA in 0.4% (0.1-1.3%). We found no statistically significant differences regarding HCV prevalence, risk factors or socioeconomic characteristics between subjects undergoing colorectal cancer screening and symptomatic subjects.
Conclusion: Symptomatic and screening subjects undergoing colonoscopy support HCV screening and present a similar HCV risk profile. Results suggest linking colorectal and HCV screening would yield good results.

• 出版日期2016-10