ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women

作者：Sumner Anne E^*; Furtado Jeremy D; Courville Amber B; Ricks Madia; Younger Coleman Novie; Tulloch Reid Marshall K; Sacks Frank M

来源：Nutrition & Metabolism, 2013, 10(1): 73.

DOI：10.1186/1743-7075-10-73

• ApoC-III
• Visceral adipose tissue
• Triglyceride
• Apoliprotein C-III
• Visceral adiposity
• Insulin resistance
• African-Americans
• Health disparities

Background: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins, B, C-III and E, on race differences in TG content of very low density lipoproteins (VLDL).
Methods: The participants were 31 women (16 African-American, 15 white) of similar age (37 +/- 9 vs. 38 +/- 11y (mean +/- SD), P = 0.72) and BMI (32.4 +/- 7.2 vs. 29.3 +/- 6.0 kg/m(2), P = 0.21). A standard diet (33% fat, 52% carbohydrate, 15% protein) was given for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (SI) was calculated from the minimal model. VAT was measured at L2-3. The influence of race, S-1, VAT and apolipoproteins on the TG content of VLDL was determined by random effects models (REM).
Results: African-Americans were more insulin-resistant (SI: 3.6 +/- 1.3 vs. 5.6 +/- 2.6 mU/L-1. min(-1), P < 0.01) with less VAT (75 +/- 59 vs. 102 +/- 71 cm(2), P < 0.01). TG, apoB and apoC-III content of light and dense VLDL were lower in African-Americans (all P < 0.05 except for apoC-III in light VLDL, P = 0.11). ApoE content did not vary by race. In REM, VAT but not SI influenced the TG concentration of VLDL. In models with race, SI, VAT and all apolipoproteins entered, race was not significant but apoC-III and VAT remained significant determinants of TG concentration in light and dense VLDL.
Conclusions: Low concentrations of apoC-III and VAT in African-Americans contribute to race differences in TG concentrations.

• 出版日期2013-12-23