Anti-acetylcholinesterase, anti-alpha-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species

作者：Mollataghi Abbas; Coudiere Emilie; Hadi A Hamid A; Mukhtar Mat Ropi; Awang Khalijah; Litaudon Marc; Ata Athar^*

来源：Fitoterapia, 2012, 83(2): 298-302.

DOI：10.1016/j.fitote.2011.11.009

• Beilschmiedia alloiophylla
• B. kunstleri
• 2-Hydroxy-9-methoxyaporphine
• Anti-acetylcholinesterase activity
• Anti-alpha-glucosidase activity
• Anti-leishmanial activity

Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), beta-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-alpha-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays.

• 出版日期2012-3