科研之友
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摘要
OBJECTIVE To examine change of the apparent relaxation rate R2 values in living kidney donors after uninephrectomy using blood oxygenation level-dependent magnetic resonance imaging. @@@ METHODS Between July 2011 and January 2012, 45 kidney donors were enrolled into this study. Blood oxygenation level-dependent magnetic resonance imaging scanning was performed before surgery, 3 and 7 days postoperatively. Participants were followed up for 1 year. @@@ RESULTS The R2 values in medulla (mR2) were significantly greater than that of cortex (cR2), both in resected kidney and remaining one. cR2 values of the remaining kidney was 17.52 +/- 1.36 s(-1) and then decrease significantly by 8.97% to 15.95 +/- 1.14 s(-1) at 3 days (P <.001) and by 7.82% to 16.15 +/- of 1.05 s(-1) at 7 days. No significant modification occurred in mR2 after surgery. Multivariate regression analysis showed that the decrease in cR2 values of the remaining kidney was positively associated with sex (r = 0.418), body surface area (r = 0.307), and preoperative cR2 values (r = 0.659). Comparing with glomerular filtration rate at 7 days, a further increment in the glomerular filtration rate was noted at 1 year in patients with cR2 values decrease of >= 10% at 1 week (62.63 +/- 11.69 vs 56.97 +/- 7.51 mL/min/1.73 m(2), P = .02) but not in the other patients (66.43 +/- 10.89 vs 62.78 +/- 13.74, P = .064). @@@ CONCLUSION Kidney donation will induce early, profound oxygenation modification within the renal cortex of the remaining kidney. Donors with cR2 value decrease of >= 10% at 1 week have a more favorable renal function compensation at 1 year. UROLOGY 83: 1205.e1-1205.e5, 2014.
- 出版日期2014-5
- 单位四川大学
