AID-induced remodeling of immunoglobulin genes and B cell fate

作者：Laffleur Brice; Denis Lagache Nicolas; Peron Sophie; Sirac Christophe; Moreau Jeanne; Cogne Michel^*

来源：Oncotarget, 2014, 5(5): 1118-1131.

• AID
• B cell fate
• BCR
• immunoglobulin genes

Survival and phenotype of normal and malignant B lymphocytes are critically dependent on constitutive signals by the B cell receptor (BCR) for antigen. In addition, either antigen ligation of the BCR or various mitogenic stimuli result in B cell activation and induction of activation-induced deaminase (AID). AID activity can in turn mediate somatic hypermutation (SHM) of immunoglobulin (Ig) V regions and also deeply remodel the Ig heavy chain locus through class switch recombination (CSR) or locus suicide recombination (LSR). In addition to changes linked to affinity for antigen, modifying the class/isotype (i.e. the structure and function) of the BCR or suddenly deleting BCR expression also modulates the fate of antigen-experienced B cells.

• 出版日期2014-3