Antitumor efficacy of Poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor

作者：Guo, Wen xun^*; Shi, Zongli; Zeng, Fan bing; Liang, Kui; Chen, Xian hong; Ai, Yong ping; Fang, Min; Sun, Xiao; Zhang, Zhi; Hu, Li Xin

来源：Journal of Materials Science: Materials in Medicine , 2007, 18(8): 1515-1520.

DOI：10.1007/s10856-007-0126-1

The drug release profiles of poly(dimer acid-dodecanedioic acid) P(DA-DDDA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The biocompatibility of P(DA-DDDA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(DA-DDDA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (31 +/- 1.5 days) compared to plain subcutaneous injection of ADM (7 +/- 0.9 days). The studies suggest that P(DA-DDDA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors.

• 出版日期2007-8
• 单位湖北工业大学; 湖南大学; 华中农业大学