Atherosclerosis and PTPN22: A Study in Coronary Artery Disease

作者：Saccucci P; Banci M; Cozzoli E; Neri A; Magrini A; Bottini E; Gloria Bottini F^*

来源：Cardiology, 2011, 119(1): 54-56.

DOI：10.1159/000329919

• PTPN22
• Coronary artery disease
• Atherosclerosis

Objectives: Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD). Methods: One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs. Results: In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07-6.72). Conclusions: The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.

• 出版日期2011