Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats

作者：Abdalla Fatima Husein^*; Cardoso Andreia Machado; Pereira Luciane Belmonte; Schmatz Roberta; Goncalves Jamile Fabbrin; Stefanello Naiara; Fiorenza Amanda Maino; Gutierres Jessie Martins; da Silva Serres Jonas Daci; Zanini Daniela; Pimentel Victor Camera; Vieira Juliano Marchi; Chitolina Schetinger Maria Rosa; Morsch Vera Maria; Mazzanti Cinthia Melazzo

来源：Molecular and Cellular Biochemistry, 2013, 381(1-2): 1-8.

DOI：10.1007/s11010-013-1659-x

• NTPDase
• 5 '-Nucleotidase
• ADA
• AChE
• Cadmium
• Quercetin

This study investigated the effect of quercetin on nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase, adenosine deaminase (ADA), and acetylcholinesterase (AChE) activities in synaptosomes from cerebral cortex of adult rats exposed to cadmium (Cd). Rats were exposed to Cd (2.5 mg/Kg) and quercetin (5, 25 or 50 mg/Kg) by gavage for 45 days. Rats were randomly divided into eight groups (n = 8-10): saline/ethanol, saline/Querc 5 mg/kg, saline/Querc 25 mg/kg, saline/Querc 50 mg/kg, Cd/ethanol, Cd/Querc 5 mg/kg, Cd/Querc 25 mg/kg, and Cd/Querc 50 mg/kg. Results demonstrated that AChE activity increased in the Cd/ethanol group when compared to saline/ethanol group. Treatment with quercetin prevented the increase in AChE activity when compared to Cd/ethanol group. Quercetin treatment prevented the cadmium-induced increase in NTPDase, 5-nucleotidase, and ADA activities in Cd/ethanol group when compared to saline/ethanol group. Our data showed that quercetin have a protector effect against Cd intoxication. This way, is a promising candidate among the flavonoids to be investigated as a therapeutic agent to attenuate neurological disorders associated with Cd intoxication.

• 出版日期2013-9