A Chemoenzymatic Synthesis of Hept-6-ene-2,5-diol Stereomers: Application to Asymmetric Synthesis of Decarestrictine L, Pyrenophorol, and Stagonolide E

作者:Chatterjee Sucheta; Ghadigaonkar Sneha; Sur Payel; Sharma Anubha*; Chattopadhyay Subrata
来源:Journal of Organic Chemistry, 2014, 79(17): 8067-8076.
DOI:10.1021/jo5012575

摘要

The stereomers of hept-6-ene-2,5-diol derivatives were conceived as useful chiral intermediates and were synthesized starting from sulcatol using two lipase-catalyzed acylation reactions as the key steps. The versatility of the intermediates was demonstrated by converting OH them to the titled tetrahydropyran, macrolide, and macrodiolide compounds using standard synthetic protocols.

  • 出版日期2014-9-5