Access to C(sp(3))-C(sp(2)) and C(sp(2))-C(sp(2)) Bond Formation via Sequential Intermolecular Carbopalladation of Multiple Carbon-Carbon Bonds

作者：Wen, Yanmei; Huang, Liangbin; Jiang, Huanfeng^*

来源：Journal of Organic Chemistry, 2012, 77(12): 5418-5422.

DOI：10.1021/jo300662x

• CROSS-COUPLING REACTIONS
• ARYL IODIDES
• INTERNAL ALKYNES
• TETRASUBSTITUTED OLEFINS
• EFFICIENT SYNTHESIS
• OXIDATIVE-ADDITION
• HECK REACTION
• ALKENES
• REAGENTS
• HALIDES

A synthetic strategy of 4-benzyl-substituted 1,3-butadiene derivatives through Pd-catalyzed three-component coupling reaction of benzyl chlorides, alkynes, and monosubstituted alkenes is described. This tandem coupling reaction forms a C(sp(3))-C(sp(2)) bond and a C(sp(2))-C(sp(2)) bond sequentially in a single-step operation.

• 出版日期2012-6-15
• 单位广东海洋大学; 华南理工大学