Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

作者:Willand Charnley Rachel; Puffer Benjamin W; Dussault Patrick H*
来源:Journal of the American Chemical Society, 2014, 136(16): 5821-5823.
DOI:10.1021/ja5026276

摘要

The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

  • 出版日期2014-4-23