Complete Response to Thalidomide and Dexamethasone in a Patient With Necrobiotic Xanthogranuloma Associated With Monoclonal Gammopathy: A Case Report and Review of the Literature

作者：Efebera Yvonne^*; Blanchard Elizabeth; Allam Charles; Han Andrew; Lee Saem; Munshi Nikhil

来源：Clinical Lymphoma Myeloma & Leukemia, 2011, 11(3): 298-302.

DOI：10.1016/j.clml.2011.03.020

• MGUS
• Multiple myeloma
• Necrobiotic xanthogranuloma
• Thalidomide

Necrobiotic xanthogranuloma (NXG) was first described in 1980 by Kossard and Winkelmann in an article in which they discussed 8 patients with xanthomatous plaques who were noted to have monoclonal gammopathy, predominantly of the Ig(immunoglobulin)G-kappa type.(1) Since then more than 50 patients with this disorder have been described, with approximately 80% of them having an associated monoclonal gammopathy.
We describe the first case, to our knowledge, of NXG with associated monoclonal gammopathy treated with 1 thalidomide plus dexamethasone, achieving complete resolution of the skin lesions and sustaining response more than 3 years after treatment. Clinical Lymphoma, Myeloma & Leukemia, Vol. 11, No.

• 出版日期2011-6