ANNIE: integrated de novo protein sequence annotation

作者：Ooi Hong Sain; Kwo Chia Yee; Wildpaner Michael; Sirota Fernanda L; Eisenhaber Birgit; Maurer Stroh Sebastian; Wong Wing Cheong; Schleiffer Alexander; Eisenhaber Frank; Schneider Georg^*

来源：Nucleic Acids Research, 2009, 37(Web Server): W435-W440.

DOI：10.1093/nar/gkp254

Function prediction of proteins with computational sequence analysis requires the use of dozens of prediction tools with a bewildering range of input and output formats. Each of these tools focuses on a narrow aspect and researchers are having difficulty obtaining an integrated picture. ANNIE is the result of years of close interaction between computational biologists and computer scientists and automates an essential part of this sequence analytic process. It brings together over 20 function prediction algorithms that have proven sufficiently reliable and indispensable in daily sequence analytic work and are meant to give scientists a quick overview of possible functional assignments of sequence segments in the query proteins. The results are displayed in an integrated manner using an innovative AJAX-based sequence viewer. ANNIE is available online at: http://annie.bii.a-star.edu.sg. This website is free and open to all users and there is no login requirement.

• 出版日期2009-7-1