Andirolides Q-V from the flower of andiroba (Carapa guianensis, Meliaceae)

作者：Sakamoto Asami; Tanaka Yuji; Inoue Takanobu; Kikuchi Takashi; Kajimoto Tetsuya; Muraoka Osamu; Yamada Takeshi; Tanaka Reiko^*

来源：Fitoterapia, 2013, 90: 20-29.

DOI：10.1016/j.fitote.2013.07.001

• Andirolides Q-V
• Limonoid
• Carapa guianensis
• Murine P388 leukemia cell line
• Human HL-60 leukemia cell line

Two new gedunins, an andirobin, two mexicanolides, and a phragmalin-type limonoid, named Andirolides Q (1), R (2), S (3), 1(4), U (5), and V (6), were isolated from an oil of the flower of Carapa guianensis AUBLET (Meliaceae). Their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR spectra and FABMS. Andirolide S (3) and Andirolide T (4) showed significant cytotoxic activity against the murine P388 leukemia cell line (IC50 of 1.4 mu M for 3; 1.8 mu M for 4) and the human HL-60 leukemia cell line (IC50 of 1.3 mu M for 3 and 4).

• 出版日期2013-10