Facile biocatalytic access to 9-fluorenylmethyl polyglycosides: Evaluation of antiviral activity on immunocompetent cells

作者：Tramice Annabella^*; Arena Adriana; De Gregorio Ambra; Ottana Rosaria; Maccari Rosanna; Pavone Bernadette; Arena Nicoletta; Iannello Daniela; Vigorita Maria Gabriella; Trincone Antonio

来源：ChemMedChem, 2008, 3(9): 1419-1426.

DOI：10.1002/cmdc.200800086

• antiviral activity
• cytokines
• immunomodulators
• marine glycoside hydrolases
• transglycosylation

The biological activities of a series of mono- and oligosaccharides (beta-xylosides and alpha-glucosides) of 9-fluorenylmethanol were investigated together with mono-beta-galactoside and beta-glucoside of this aglycone, produces by biocatalytic routes. By using marine glysocide hydrolases and inexpensive donors such a maltose or xylan, access to mono-alpha-glucoside or mono-beta-xyloside of 9-fluorenylmethanol was obtained. Additionally, interesting polyglycoside derivatives were isolated. Biological testing indicated that in vitro treatment with these carbohydrate derivatives may influence the balance of cytokines in the environment of human peripheral blood mononuclear cells (PBMC), restricting the harmful effect of herpes simplex type 2 replication. In fact, these carbohydrate derivatives tested in WISH cells did not show any significant antiviral activity.

• 出版日期2008-9