Prolonged partial obstruction during sleep is a NREM phenomenon

作者：Himanen Sari Leena; Martikkala Lauri; Sulkamo Saramia; Rutanen Antti; Huupponen Eero; Tenhunen Mirja; Saunamaki Tiia

来源：Respiratory Physiology & Neurobiology, 2018, 255: 43-49.

DOI：10.1016/j.resp.2018.05.009

• OSA
• Partial obstruction
• Emfit
• Sleep EEG
• Flow limitation
• Sleep-disordered breathing
• Breathing effort

Objective: Prolonged partial obstruction (PPO) is a common finding in sleep studies. Although not verified, it seems to emerge in deep sleep. We study the effect of PPO on sleep architecture or sleep electroencephalography (EEG) frequency.
Methods: Fifteen OSA patients, 15 PPO + OSA patients and 15 healthy subjects underwent a polysomnography. PPO was detected from Emfit mattress signal. Visual sleep parameters and median NREM sleep frequency of the EEG channels were evaluated.
Results: The amount of deep sleep (N3) did not differ between the PPO + OSA and control groups (medians 11.8% and 13.8%). PPO + OSA-patients' N3 consisted mostly of PPO. PPO + OSA patients had lighter sleep than healthy controls in three brain areas (Fp2-A1, C4-A1, O1-A2, p-values < 0.05).
Conclusion: PPO evolved in NREM sleep and especially in N3 indicating that upper airway obstruction does not always ameliorate in deep sleep but changes the type. Even if PPO + OSA-patients had N3, their NREM sleep was lighter in three EEG locations. This might reflect impaired recovery function of sleep.

• 出版日期2018-9